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EC number: 213-650-7 | CAS number: 998-30-1
In a good quality 90-day inhalation study (reliability score 2) conducted in a study comparable to OECD 413 and GLP, Sprague-Dawley rats (10 with an additional 5 rats/sex in the control and high exposure groups) were exposed to trimethoxysilane vapor for 90 days over a 13-week period for 6 hours/day, 5 days/week, followed by a 4-week recovery period. Mean exposure concentrations of 0.02, 0.10 and 0.51 ppm were achieved. This exposure regimen did not produce any exposure-related effects upon clinical signs, body weight and body weight gains, food and water consumption, ophthalmic evaluations, hematology, clinical chemistry, serum protein fractions, urine chemistry, urinalysis, absolute and relative organ and tissue weights, or gross and microscopic evaluations of organs and tissues. Therefore, the NOAEC was determined to be at least 0.51 ppm under the conditions of this study.
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