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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
publication
Title:
Mutation Research
Author:
Kusakabe, Hirokazu; Yamakage, Kohji; Wakuri, Shinobu; Sasaki, Kiyoshi; Nakagawa, Yuzuki; Watanabe, Mika; Hayashi, Makoto; Sofuni, Toshio; Ono, Hiroshi; Tanaka, Noriho
Year:
2002
Bibliographic source:
Kusakabe, Hirokazu; Yamakage, Kohji; Wakuri, Shinobu; Sasaki, Kiyoshi; Nakagawa, Yuzuki; Watanabe, Mika; Hayashi, Makoto; Sofuni, Toshio; Ono, Hiroshi; Tanaka, Noriho ; Mutation Research; vol. 517; nb. 1-2; (2002); p. 187 - 198

Materials and methods

Type of assay:
in vitro mammalian chromosome aberration test

Method

Species / strain
Species / strain:
Chinese hamster lung fibroblasts (V79)
Additional strain characteristics:
not specified
Metabolic activation:
with and without

Results and discussion

Test results
Species / strain:
Chinese hamster lung fibroblasts (V79)
Metabolic activation:
with and without
Genotoxicity:
not specified
Cytotoxicity:
yes
Additional information on results:
Chromosome aberation-positive with the minimum effective dose manifesting over 50 percent
cytotoxicity.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
positive