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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
publication
Title:
Mutation Research
Author:
Kusakabe, Hirokazu; Yamakage, Kohji; Wakuri, Shinobu; Sasaki, Kiyoshi; Nakagawa, Yuzuki; Watanabe, Mika; Hayashi, Makoto; Sofuni, Toshio; Ono, Hiroshi; Tanaka, Noriho
Year:
2002
Bibliographic source:
Kusakabe, Hirokazu; Yamakage, Kohji; Wakuri, Shinobu; Sasaki, Kiyoshi; Nakagawa, Yuzuki; Watanabe, Mika; Hayashi, Makoto; Sofuni, Toshio; Ono, Hiroshi; Tanaka, Noriho ; Mutation Research; vol. 517; nb. 1-2; (2002); p. 187 - 198

Materials and methods

Type of assay:
in vitro mammalian chromosome aberration test

Method

Species / strain
Species / strain / cell type:
Chinese hamster lung fibroblasts (V79)
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with and without

Results and discussion

Test results
Species / strain:
Chinese hamster lung fibroblasts (V79)
Metabolic activation:
with and without
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
cytotoxicity
Additional information on results:
Chromosome aberation-positive with the minimum effective dose manifesting over 50 percent
cytotoxicity.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
positive