Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
publication
Title:
No information
Bibliographic source:
U.S. Environmental Protection Agency: High Production Volume (HPV) Challenge: Monocyclic Aromatic Amines (MAA) Category.pdf - FDRL Report of Study 6771- E, April 18, 198

Materials and methods

Test animals

Species:
rat

Administration / exposure

Type of coverage:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
1 347 mg/kg bw
Based on:
not specified
Sex:
male
Dose descriptor:
LD50
Effect level:
1 915.1 mg/kg bw
Based on:
not specified
Clinical signs:
Somnolence (general depressed activity)

Other findings:
changes in urine composition

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU