Registration Dossier
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EC number: 219-863-1 | CAS number: 2554-06-5
Endpoint summary
Administrative data
Description of key information
The key study for skin sensitisation found the test material not sensitising to guinea pig skin (DCC 1987). The study was conducted according to an appropriate protocol and in compliance with GLP.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The most recent and reliable study was selected as key. The test material was found not sensitising in albino guinea pigs when tested under the conditions of the Split Adjuvant assay (DCC 1987). No evidence of skin irritation or skin sensitization was observed in any of the animals following challenge phase. No skin reactions were present in the control group after treatment with vehicle. In the test group after the 4th induction 80% of animals elicited a response of 1 (very slight erythema) or greater (slight to moderate erythema) with mean erythema score of 1.40. At the challenge no skin reactions were observed in either the control or test animals after treatment with test substance diluted to 15%.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available test data, 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane is not classified as a skin sensitiser according to Regulation (EC) No 1272/2008.
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