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Diss Factsheets
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EC number: 219-863-1 | CAS number: 2554-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The objective of the study was to determine levels of D4 in blood and expired air after dermal application.
- GLP compliance:
- no
Test material
- Reference substance name:
- Octamethylcyclotetrasiloxane
- EC Number:
- 209-136-7
- EC Name:
- Octamethylcyclotetrasiloxane
- Cas Number:
- 556-67-2
- Molecular formula:
- C8H24O4Si4
- IUPAC Name:
- Octamethylcyclotetrasiloxane
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 13C
Test animals
- Species:
- human
- Strain:
- other: NA
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- Males: 1.4 g; Females: 1.0 g
- No. of animals per group:
- Three males and three females
- Control animals:
- no
Results and discussion
- Conversion factor human vs. animal skin:
- NA
Any other information on results incl. tables
D4 levels were significantly elevated above baseline in blood and plasma at 1, 2, 4 and 6 hours and in exhaled air at all time points after application. The peak levels were observed at one hour (0.57 -5.67 ng/g blood and 0.85 -7.02 ng/g plasma) and dropped rapidly at subsequent time points. The three female subjects had a significantly higher blood and plasma levels of D4 compared with the three males subjects. The mean blood peak level of D4 was 4.45 ng/gm (SD. 1.10) for women and 1.30 ng/gm (S.D. 0.77) for men. There were considerably higher levels of D4 in exhaled air (at one hour the mean peak D4 level in exhaled air was 111 ng/L (S.D. 113) for women and 30 ng/L (S.D. 37) for men) than would have been expected from the blood levels. This could not be explained. Dermal absorption rate was not included in the report.
D4 blood levels in blood and plasma for women and men were significantly different at 1, 2, and 4 hrs. post-application.
The correlation between blood and plasma levels of D4 at all
time points was excellent. In contrast, these was a
relatively poor correlation between blood levels and exhaled
air levels of D4 especially at one hour post application,
i.e. considerably higher levels were found in exhaled air
than would have been expected based on the blood levels. The
authors do not have an explanation for this phenomenon.
Additional blood and exhaled air D4 levels at earlier time
points (0-2 hrs) would provide a more detailed evaluation of
this phenomenon and help to clarify this discrepancy.
Applicant's summary and conclusion
- Conclusions:
- In a non-GLP, non-guideline dermal absorption study using human volunteers (Dow Corning Corporation, 2000), D4 was absorbed into the blood, and found to be exhaled, with peak blood/plasma levels at one hour after exposure. Levels decreased rapidly after this. Female absorbed more D4 than males.
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