Registration Dossier
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EC number: 219-863-1 | CAS number: 2554-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
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- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
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- Nanomaterial surface chemistry
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- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to invertebrates: 48 hr EL50 272 mg/l loading rate (WAFs), Acartia tonsa, (guideline ISO/FDIS 14669 a PARCOM ring test protocol).
Key value for chemical safety assessment
Additional information
A 48-h LL50 value of 272 mg/l and NOELR of 100 mg/l loading rate (WAFs) (not possible to extrapolate to measured concentrations) have been determined for the effects of the registration substance on mobility of the marine copepod Acartia tonsa. The LL50 is above the water solubility limit of the substance (0.0073 – 0.0088 mg/l at 23°C).
For monoconstituent substances it would not normally be appropriate to test at concentrations above the solubility limit. However, the results as reported do provide strong evidence of the absence of toxicity at the solubility limit of the substance following short-term exposures.
This is the only reliable study available for this substance and it has been chosen as key.
A 48-h EC50 value of 169 mg/l has been determined for the effects of the read-across substance trimethox(vinyl)silane (CAS 2768-02-7) on mobility of Daphnia magna. The data indicate that the vinyl side chain is unlikely to contribute significant excess ecotoxicity to the substance.
The data above are supported by read-across evidence relevant to the impurities. The registration substance has an average purity of >80% Vi4-D4, with <15% 2,4,6,8,10-pentamethyl-2,4,6,8,10-pentavinylcyclopentasiloxane Vi5-D5 (CAS 17704-22-2; Impurity 1) and <10% 2,4,6-trimethyl-2,4,6-trivinylcyclotrisiloxane Vi3-D3 (CAS 3901-77-7; Impurity 2) present as impurities. After due consideration of the properties, the presence of these impurities is not expected to affect the overall hazard profile of the substance. Read-across studies are in place as supporting studies, to consider the properties of the impurities. Data for Vi5-D5 are read-across from decamethylcyclopentasiloxane D5 (CAS 541-02-6), data for Vi3-D3 are read-across from hexamethyltrisiloxane D3 (CAS 541-05-9). These siloxanes have similar properties with regard to aquatic ecotoxicity. Further information is given in a supporting report (PFA, 2017) attached in Section 13 of the IUCLID 6 dossier.
A reliable short-termDaphniastudy is available for the siloxane D5 (CAS 541-02-6) and is read-across to Impurity 1 (Vi5-D5). This study (48-h, flow through test withDaphnia magna) gave a result 48-h EC50>2.9 µg/l. EC50was not reached within the limit of solubility in test media.
A reliable short-termDaphniastudy is available for the siloxane D3 (CAS 541-05-9) and is read-across to Impurity 2 (Vi3-D3). This study (48-h, flow through test withDaphnia magna) gave a result 48-h EC50>1.6 mg/l. EC50 was not reached within the limit of solubility in test media.
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