Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 250-938-1 | CAS number: 32162-27-9
Endpoint summary
Administrative data
Description of key information
- Oral route: The query structure was predicted as GHS category III in Leadscope using Acute Rat Oral Model v2 model. Estimated LD50 by oral route: 100 mg/kg bw (QSAR prediction, K, Kr.2).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 12 October 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
Leadscope
2. MODEL (incl. version number)
QSAR used: Leadscope Model Applier v3.0.0-30
Model used for this prediction: Acute Rat Oral Model v2
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
Smiles: CC12OC1CC1CC2C1(C)C
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached QMRF
5. APPLICABILITY DOMAIN
See attached report
6. ADEQUACY OF THE RESULT
See attached report - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR study result
- GLP compliance:
- no
- Test type:
- other: QSAR
- Species:
- other: not applicable
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- not applicable
- Route of administration:
- other: not applicable
- Vehicle:
- other: not applicable
- Doses:
- not applicable
- No. of animals per sex per dose:
- not applicable
- Control animals:
- other: not applicable
- Details on study design:
- QSAR study
- Statistics:
- not applicable
- Key result
- Remarks on result:
- other: QSAR result: GHS category III
- Mortality:
- not applicable
- Clinical signs:
- other: not applicable
- Gross pathology:
- not applicable
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Leadscope evaluation for Acute Oral Toxicity using Acute Rat Oral Model v2 model predicted (1,2,4,6)-2,2,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane.as GHS category III.
- Executive summary:
Leadscope Model Applier v3.0.0-30 was used to predict the acute oral toxicity of (1,2,4,6)-2,2,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane.
The query structure was predicted as GHS category III in Leadscope using Acute Rat Oral Model v2 model.
Based on these results, the test substance is considered as Toxic if swallowed according to Regulation (EC) No. 1272/2008 and UN GHS criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 100 mg/kg bw
- Quality of whole database:
- Results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation (Kr.2).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
leadscope Model Applier v3.0.0-30 was used to predict the acute oral toxicity of (1,2,4,6)-2,2,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane.
The query structure was predicted as GHS category III in Leadscope using Acute Rat Oral Model v2 model. Therefore the test substance is considered as Toxic if swallowed according to the Regulation (EC) No. 1272/2008.
Justification for classification or non-classification
Harmonized classification:
The substance has no harmonized classification according to the Regulation (EC) No. 1272/2008.
Self classification:
Acute toxicity (Oral):
Based on the Leadscope prediction, the test substance is classified into Category III (Toxic if swallowed, H301) according to the Regulation (EC) No. 1272/2008 and to the GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
