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EC number: 292-883-6 | CAS number: 91002-07-2
Since there was no indication that the test substance elicits an SI ≥ 3 when tested up to 25%, Barium Chloride Di-Hydrate was considered not to be a skin sensitizer. It was established that the EC3 value (the estimated test substance concentration that will give a SI =3) (if any) exceeds 25%.
No irritation of the ears was observed for any of the animals treated with the test substance or for vehicle control animals. White test substance remnants on one ear were observed for two animals treated at 25%, but the remnants did not hamper scoring for skin irritation. The positive control animals showed slight erythema, but no oedema was observed. The slight irritation of the ears as shown by the positive control animals was considered not to have a toxicologically significant effect on the activity of the nodes.
Macroscopy of the auricular lymph nodes and surrounding area:
The majority of auricular lymph nodes were considered normal in size, except for the enlarged nodes in the majority of animals treated at 25% test substance and in all positive control animals. No macroscopic abnormalities of the surrounding area were noted in any of the animals.
Body weights and body weight gain of experimental animals remained in the same range as controls over the study period. The body weight loss, noted among the majority of animals, occurred in the absence of a treatment-related distribution and was therefore considered to be of no toxicological significance.
Toxicity and mortality:
No mortality occurred and no symptoms of systemic toxicity were observed in the animals of the main study.
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