Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Non-guideline-conform investigations without GLP with several methodical deficiencies: (i) key information on test substance is missing such as purity, stability, particle size; (ii) test methodology is reported with inadequate details: insufficient description on animal treatment/husbandry, laboratory conditions and other experimental procedures, (iii) inadequate analytical verification of actual exposure concentrations, and lack of documentation of particle size distributions.

Data source

Reference
Reference Type:
publication
Title:
Data on the experimental toxicology of silver and the establishment of the maximum allowable concentration for its compounds in the air of a work area
Author:
Smirnov, V.G.
Year:
1983
Bibliographic source:
Gig Tr Prof Zabol. 12, 33-37 (cited in RTECS database)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Repeated inhalation exposure of rats for 4 month. Further methodological detail insufficiently or not reported.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Silver nitrate
EC Number:
231-853-9
EC Name:
Silver nitrate
Cas Number:
7761-88-8
IUPAC Name:
silver(1+) nitrate
Details on test material:
Not available.

Test animals

Species:
rat
Sex:
male
Details on test animals or test system and environmental conditions:
Not available.

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Not available.

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Disregarded study for lack of reliability.

Categories Display