Silver iodide

Endpoint summary

Description of key information

There is no acute toxicity data available for silver iodide. Read-across is applied to other comparable silver substance. 

The most comparable compounds is AgCl, a LD50 oral of > 5110 mg/kg bw (equivalent to 8370.6 mg/kg bw of silver iodide) has been determined. it is noted that the solubility of AgI (30µg/L) is even lower than for AgCl (1.9 mg/L). Testing for acute oral toxicity for AgI is thus not considered to be scientifically justified.

Note: Acute toxicity study via dermal and inhalation route are not a requirement under Annex VII of Regulation 1907/2006.

 

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Substance considered to fall within the scope of the read-across: justification of a read-across approach for human health hazard endpoint (document attached in IUCLID section 13).

Reason / purpose for cross-reference:

read-across source

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 8 370.6 mg/kg bw

Remarks on result:

other: 5110 mg of silver chloride is equivalent to 8370.6 mg of silver iodide

Mortality:

Deaths did not occur.

Clinical signs:

other: The signs of toxicity were slight to moderate hypokinesia, stilted gait, piloerection, sunken sides, vocalization on handling, red crusted noses, and diarrhea with black discoloured feces. Individual rats additionally showed chromodacryorrhea and strenuou

Gross pathology:

At necropsy no changes were recorded.
Brain and spinal cord of the female rat that did not recover completely were examined microscopically, but changes could not be detected.

Other findings:

Diarrhea was caused by the vehicle alone, too.

Interpretation of results:

GHS criteria not met

Remarks:

Silver iodide is not toxic

Conclusions:

The LD 50 values for silver chloride (silver iodide) tested in a single dose were above 5110 (8370.6) mg/kg for male and female rats (limit test).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 8 370.6 mg/kg bw

Quality of whole database:

reliable database

Justification for classification or non-classification

There is no reliable and relevant data available for silver iodide (AgI). A read-across with silver chloride (AgCl) is applied. It is noted that the solubility of AgI (30 µg/L) is even lower than AgCl (1.9 mg/L). 

• Zechel et al 1989 performed a reliable in-vivo acute toxicity study performed via oral route (OECD 401 – GLP) with solid powder (purity 75% of Ag). The study concluded that silver chloride is not acute toxic via oral route. The LD50 was defined by the author at > 5110 mg/kg bw. It then concluded that silver iodide is not acute toxic via oral route.

In consequence, silver iodide does not require classification for acute toxicity endpoints.

Note: Acute toxicity study via dermal and inhalation route are not a requirement under Annex VII of Regulation 1907/2006.