Registration Dossier
Registration Dossier
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EC number: 200-813-2 | CAS number: 74-83-9
Endpoint summary
Administrative data
Description of key information
Methyl Bromide is toxic by the oral and inhalation routes described in this set of experiments. Evidence of this toxicity was seen in a reduction of body weights throughout a number of studies. Mortality findings, alterations of the forestomach mucosa of rats and a reduction in absolute liver weights were also taken as signs of the toxic effect of Methyl Bromide.
Key value for chemical safety assessment
Additional information
An overview of the studies described in 7.5.1 to 7.5.2 is given in table 5.3.4 -1
Table 5.3.4 -1 Overview of short-term toxicity studies with Methyl Bromide
Parameter |
Test material |
Species |
Result (NOEL) |
Reference |
NOEL (oral, 90 day) |
Methyl Bromide |
Rat |
< 50 mg/kg bw |
Boorman, 1986 |
NOEL (oral, 90 day) |
Methyl Bromide |
Rat |
2 mg/kg bw |
Danse, 1984 |
NOEL (oral, 1 year) |
Methyl Bromide |
Dog |
> 0.27 mg/kg bw |
Newton, 1995 |
NOEL (inhalation, 28 day) |
Methyl Bromide |
Rabbit |
< 65 ppm |
Angeret al, 1981 |
NOEL (inhalation, 28 day) |
Methyl Bromide |
Rat |
69 mg/kg bw |
Angeret al, 1981 |
NOEL (inhalation, 28 day) |
Methyl Bromide |
Rat |
< 170 mg/kg bw |
Eustiset al, 1988 |
NOEL (inhalation, 4 hour) |
Methyl Bromide |
Rat |
< 159 mg/kg bw |
Katoet al, 1986 |
NOEL (inhalation, 28 day) |
Methyl Bromide |
Dog |
21.6 mg/kg bw/day |
Newton, 1994 |
NOEL (inhalation, 42 day) |
Methyl Bromide |
Dog |
18 mg/kg bw |
Schaefer, 2002 |
NOEL (inhalation, 90 day) |
Methyl Bromide |
Mouse |
39 mg/kg bw |
Drew, 1984 |
NOEL (inhalation, 90 day) |
Methyl Bromide |
Mouse |
39 mg/kg bw |
Cockerhamet al, 1992 |
NOEL (inhalation, 90 day) |
Methyl Bromide |
Rat |
32 mg/kg bw |
Cockerhamet al, 1992 |
Justification for classification or non-classification
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