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Diss Factsheets
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EC number: 203-479-6 | CAS number: 107-29-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP. No replications.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was administered by gavaging to a beagle dog as a 2% aqueous solution followed after 4 h by 95% ethanol (0.5 mL/kg) given orally as a 25% aqueous solution. Blood pressure and heart rate measurements were carried out every 30 min post-AAO for a 4 h period. The monitoring was continued post-ethanol at 30 min intervals for a total of 165 min. Arterial samples were collected at each measurement time.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- other:
Test material
- Reference substance name:
- Acetaldehyde oxime
- EC Number:
- 203-479-6
- EC Name:
- Acetaldehyde oxime
- Cas Number:
- 107-29-9
- Molecular formula:
- C2H5NO
- IUPAC Name:
- acetaldehyde oxime
- Details on test material:
- - test material: acetaldehyde oxime (AAO)
Constituent 1
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Marshall Research Animals Inc., North Rose, NY, USA
- Age: 9-10 months
- Weight: 11.4 - 14 kg
- Housing: individually in elevated standard size dog cages
- Diet: 400 g of standard dog chow (Wayne Feeds) at 10 am each day and uneaten food removed 4.5 h later
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C):22±3°C
- Humidity (%): 50±5%
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- no
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
100 mg/kg AAO
Basis:
actual ingested
- Remarks:
- Doses / Concentrations:
0.5 mL/kg 95% ethanol
Basis:
actual ingested
- No. of animals per sex per dose:
- 1
- Control animals:
- no
Examinations
- Examinations:
- electrocardiogram, systemic arterial blood pressure, heart rate, respiration rate, body temperature, blood sampling and analysis
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Oral acetaldehyde oxime (AAO) given alone or in combination with ethanol had no dramatic effects on the cardiovascular dynamics of the conscious dog. But moderate changes were observed. There was a gradual increase in heart rate following AAO alone and there occurred a slight fall in blood pressure when AAO was followed by ethanol. Acetaldehyde blood levels were not elevated following the administration of AAO in combination with ethanol.
- Executive summary:
A beagle dog was used to study the effects of oral acetaldehyde oxime (AAO) alone and in combination with ethanol. Measurements of the responses to AAO alone were made over a period of 4 h at the end of which ethanol at 0.5ml/kg diluted as a 25% aqueous solution was given orally and the studies continued for 3 h. There was essentially no overall change in the systemic blood pressure during the 4 h post AAO study period. However, the heart rate showed a progressive increase from a baseline value of about 120 beats/minute up to 180 beats/minute at 3 h. By extending this period to 4 h, the investigaters had hoped to better establish the validity of the elevated heart rate. It turned out that at the end of 4 h the heart rate was unchanged (at 180 beats/minute). Results of measurements made following ethanol administration showed that over the 3 h study period there were essentially no changes in heart rate but blood pressure did tend to decrease slightly from values obtained with AAO alone prior to administration of ethanol.
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