Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine

Endpoint summary

Description of key information

Biodegradation in water:

Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical  is expected to be not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test. If released in to the environment, 6.32% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 180 days ( 4320  hrs). The half-life (180   days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical in sediment is estimated to be 1620.833 days (38900 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.581 %), indicates that test chemical is not persistent in sediment.

Biodegradation in Soil:

The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 93.1 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be  360 days ( 8640 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is persistent in the soil environment and the exposure risk to soil dwelling animals is high.

Additional information

Biodegradation in water:

Various studies have been reviewed for test chemical and its read across chemical for biodegradation endpoint and their results are summarized below.

 

 In first study the Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical is expected to be not readily biodegradable.

 

Next study was reviewed from authoritative database ( J check) in this study the Biodegradation experiment was carried out of test chemical by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using three parameters that are BOD and test material analysis by GC .The initial concentration of test chemical was 100 mg/L. After 4 weeks of incubation Percent biodegradation of test chemical was observed to be 22 % by BOD (O2 consumption) parameter, 28 % by TOC removal parameters and 74 % by test material analysis by HPLC parameter in 28 days. By considering % degradation value of BOD parameter it is concluded that test chemical is not readily biodegradable.

 

Another study was also reviewed from J check in this study the Biodegradation experiment was conducted for test chemical by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC .The initial concentration of test chemical was 100 mg/L. After 4 weeks of incubation Percent biodegradation of test chemical was observed to be 0.0 % by BOD (O2 consumption) parameter and < 0.0 % by test material analysis by GC parameter in 28 days. On the basis of percent degradation value it is concluded that test chemical is not readily biodegradable.

 

By considering results of all the studies mentioned above it can be concluded that test chemical is not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test. If released in to the environment, 6.32% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 180 days ( 4320  hrs). The half-life (180   days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical in sediment is estimated to be 1620.833 days (38900 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.581 %), indicates that test chemical is not persistent in sediment.

Biodegradation in Soil:

The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 93.1 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be  360 days ( 8640 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is persistent in the soil environment and the exposure risk to soil dwelling animals is high.