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Long-term toxicity to aquatic invertebrates

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Description of key information

NOEC (21d) = 6.31 mg/L for Daphnia magna (OECD 211), recalculated value

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
6.31 mg/L

Additional information

For long-term toxicity towards aquatic invertebrates, no data are available for 1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt, (TMT, CAS No. 17766-26-6). Long-term toxicity was assessed in one study with Daphnia magna (2006-0306-FGO) using 1,3,5-triazine-2,4,6(1H,3H,5H)-trithione (TMT-H3, CAS 638-16-4) as read across of a surrogate substance.

This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. "Grouping of substance and read across approach" and is explained within the read across justification in IUCLID section 13.

TMT-H3 is the acidic form of 1,3,5-triazine-2,4,6(1H,3H,5H)-trithione. Except for different cations (hydrogen vs sodium), the anion of both the source and target substance have an identical structure. Since dissociation of the sodium salt under environmental conditions (pH 4-9) yields the same ionic species as the acidic form of the substance, this read across can be considered as justified.


The GLP-study with TMT-H3 was carried out under semi-static exposure conditions according to OECD guideline 211 including analytics. The NOEC (21 d) was determined as 4.6 mg/L (nominal; 4.3 mg/L mean measured) based on reproduction and growth. An EC50 (21d) of 8.39 mg/L (mean measured concentration) was determined based on mortality and an EC50 (21d) of 8.62 mg/L (mean measured concentration) based on reproduction. Measured concentrations were in the range from 95 to 100% of nominal values.


The NOEC (21 d) of 4.6 mg/L as result for the read across substance TMT-H3 was used for further assessment. For this purpose the value was recalculated to be 6.31 mg TMT/L.