Registration Dossier
Registration Dossier
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EC number: 470-720-1 | CAS number: 189253-72-3
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Theoretical modelling using MC4PC version 2.1 Artificial intelligence based bioactivity software
MultiCASE Inc, 23811 Chagrin Blvd Ste 305,
Beachwood, Ohio, 44122, USA www.multicase.com - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 470-720-1
- EC Name:
- -
- Cas Number:
- 189253-72-3
- Molecular formula:
- C10H25N3O
- IUPAC Name:
- N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Sex:
- male/female
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 1 other: no unit, this is filled to pass TCC as the remark in the Remarks field is not preventing TCC failure.
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- other: Effect levels were not determined. Modelling tool does not allow this determination.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Results: F1 generation
Effect levels (F1)
- Key result
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 1 other: no unit
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: Effect levels were not determined. Modelling tool does not allow this determination.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Three models were used to assess reprotoxicity of N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine and all three predict that the molecule has no structural features associated with reproductive toxicity.
- Executive summary:
Three models were used to assess reprotoxicity of N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine and all three predict that the molecule has no structural features associated with reproductive toxicity.
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