Isoquinoline

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List IV

Author:

Smyth HF, Carpenter CP, Weil CS

Year:

1951

Bibliographic source:

Arch.Ind.Hyg.Occup.Med. 4: 119-122

Materials and methods

Principles of method if other than guideline:

Single oral dose toxicity is estimated by the gastric intubation of groups of five nonfasted, Carworth-Wistar male rats, four to five weeks of age and 90 to 120 grams in weight which have been reared in our own colony and maintained from time of weaning on Rockland rat diet, complete. The dosages are arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical is administered undiluted. When a lesser concentration is necessary, solution in water or corn oil or suspensions in semi-solid agar are the preferred expedients. Occasionally, a 1% solution of TERGITOL Penetrant 7 (essentially an aqueous solution of 25% sodium 3,9-diethyl-6-tridecanol sulfate) has been used as a dispersing agent. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isoquinoline

EC Number:

204-341-8

EC Name:

Isoquinoline

Cas Number:

119-65-3

Molecular formula:

C9H7N

IUPAC Name:

isoquinoline

Details on test material:

- Name of test material (as cited in study report): Iso quinoline
no further data

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

Nonfasted, Carworth-Wistar male rats, four to five weeks of age and 90 to 120 grams in weight which have been reared in our own colony and maintained from time of weaning on Rockland rat diet, complete.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

no data

Doses:

The dosages are arranged in a logarithmic series differing by a factor of two.

No. of animals per sex per dose:

5 males per dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
no further data

Statistics:

The most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

360 mg/kg bw

Based on:

test mat.

Mortality:

no data

Clinical signs:

other: no data

Gross pathology:

no data

Other findings:

no data