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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Source is peer reviewed

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No additional information on the guideline followed or the method employed is given
GLP compliance:
not specified
Type of study:
not specified
Justification for non-LLNA method:
Study was conducted prior to the introduction of the LLNA.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloropropionic acid
EC Number:
209-952-3
EC Name:
2-chloropropionic acid
Cas Number:
598-78-7
Molecular formula:
C3H5ClO2
IUPAC Name:
2-chloropropanoic acid
Details on test material:
No additional data

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Vehicle:
no data
Concentration / amount:
No data
Challengeopen allclose all
Vehicle:
no data
Concentration / amount:
No data
No. of animals per dose:
No data
Details on study design:
No data
Challenge controls:
No data
Positive control substance(s):
not specified

Results and discussion

Positive control results:
No data

In vivo (non-LLNA)

Results
Reading:
other: Not sensitising
Clinical observations:
Not sensitising
Remarks on result:
other: Reading: other: Not sensitising. Clinical observations: Not sensitising.

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
other: not sensitising
Conclusions:
The substance failed to produce a positive result in guinea pigs in a sensitisation test and is therefore considered to be non-sensitising.
Executive summary:

The substance is reported to have been subjected to a sensitisation test in guinea pigs. No information on the guideline followed or the method employed is given.

The substance failed to give a positive result in the sensitisation test and is therefore considered to be non-sensitising to the skin.

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