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EC number: 914-103-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the read-across data from ammonium sulphate, the reaction mass of ammonium sulphate and potassium sulfate and sodium sulphate is expected to be non-irritating to the skin and the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Based on the available information on absorption, distribution, metabolism and excretion properties as well as the available toxicological data of all three components of the reaction mass, it can be concluded, that ammonium sulphate is the most critical substance within the reaction mass. Thus, available data on ammonium sulphate will be used for hazard assessment of the toxicological properties of the reaction mass of ammonium sulphate and potassium sulfate and sodium sulphate:
Skin
In a primary dermal irritation study, an 80% aqueous suspension of the test substance (purity not further specified) was not irritating when applied to the dorsal skin of rabbits for up to 20 h under occlusive conditions (BASF, 1969). This treatment, harsher than suggested in the OECD guideline, caused only slight, barely visible skin erythema (equivalent to a Draize score of 0) at 24 h. Furthermore, the findings were completely subsided after 8 days. Thus, ammonium sulphate was found to be not irritating to skin. The same was found in a comparative study on dermal irritation with 12 different lots of the test substance (BASF, 1968). No irritation to the intact skin of white rabbit was found when applied as a single dose (20 h) or even after repeated application (5 x 8 h) although moderate irritation was observed following repeated application (5 x 8 h) to the abraded skin, these effects were also completely reversible within 8 days.
Based on the available results, ammonium sulphate can be regarded as not irritating to skin.
Eye
In a primary irritation study, 50 µL ammonium sulphate was instilled into the right eyes of 2 Vienna White rabbits (BASF, 1969). Talcum was placed into the adjacent eye for control purpose. Slight edema and conjunctival redness was noted at 1 h after instillation of the test substance; no edema, but still slight redness was present at 24 h. All effects were completely subsided after 8 days. The mean irritation scores for corneal opacity, iris and conjunctival erythema and chemosis were 0, 0, 0.33 and 0, respectively.
Thus, ammonium sulphate can be regarded as not irritating to eyes.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on read-across, the available data on skin and eye irritation are conclusive but not sufficient for classification according to the criteria of Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP).
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