Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only a secondary literature with very few information on the study design and on the results.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- GLP compliance:
- no
- Remarks:
- study performed before GLP establishment
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
- Details on test material:
- Data from handbook, no specific composition is available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A single application of fluoroacids to the skin of rabbits produced a marked irritant and caustic action to the products with formation of a dry ulcer extending as far as the muscular layer, without however becoming infected, followed by slow healing of the ulcer without moist granulations, with the formation of a soft delicate scar that was attached to the underlying tissue.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
