Registration Dossier
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EC number: 237-048-9 | CAS number: 13597-46-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: human study; anaylsis of human hair
- Adequacy of study:
- supporting study
- Reliability:
- other: Not rated. No significant deficiencies in study design and evaluation were reported by ATSDR, 2003 expert judgment.
- Rationale for reliability incl. deficiencies:
- other: No significant deficiencies in study design and evaluation were reported by ATSDR, 2003 expert judgment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Correlation between the levels of certain carcinogenic and anticarcinogenic trace elements and esophageal cancer in Northern Iran.
- Author:
- Azin F; Raie RM; Mahmoudi MM
- Year:
- 1 998
- Bibliographic source:
- Ecotoxicol. Environ. Saf. 39, 179-184
Materials and methods
- Endpoint addressed:
- carcinogenicity
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Levels of four anticarcinogenic trace elements (Zn, Se, Mn, Mg) were measured in hair samples from oesophageal cancer patients, their unaffected family members, and members of families with no history of cancer. Measurements were also made in non-oesophageal cancer patients, using atomic absorption spectroscopy, inductively coupled plasma-emission spectroscopy, and neutron activation analysis.
Test material
- Reference substance name:
- not defined
- IUPAC Name:
- not defined
Constituent 1
Method
- Subjects:
- Levels of four anticarcinogenic trace elements (Zn, Se, Mn, Mg) were measured in hair samples from esophageal caner patients, their unaffected family members, and members of families with no history of cancer. Measurements were also made in non-esophageal cancer patients, using atomic absorption spectroscopy, inductively coupled plasma-emission spectroscopy, and neutron activiation analysis.
Results and discussion
- Results of examinations:
- According to ATSDR expert judgement, the study revealed no association between selenium intake and incidence of cancer. For selenium, the results of the study showed that the levels were not significantly different in the above mentioned groups.
Any other information on results incl. tables
For selenium, the results showed that the levels were not significantely different in the above mentioned groups.
Applicant's summary and conclusion
- Conclusions:
- According to ATSDR expert judgement, the study revealed no association between selenium intake and incidence of cancer. Levels of four anticarcinogenic trace elements (Zn, Se, Mn, Mg) were measured in hair samples from esophageal caner patients, their unaffected family members, and members of families with no history of cancer. Measurements were also made in non-esophageal cancer patients, using atomic absorption spectroscopy, inductively coupled plasma-emission spectroscopy, and neutron activiation analysis. For selenium, the results showed that the levels were not significantely different in the above mentioned groups.
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