Zinc selenite

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: human study; anaylsis of human hair

Adequacy of study:

supporting study

Reliability:

other: Not rated. No significant deficiencies in study design and evaluation were reported by ATSDR, 2003 expert judgment.

Rationale for reliability incl. deficiencies:

other: No significant deficiencies in study design and evaluation were reported by ATSDR, 2003 expert judgment.

Data source

Reference

Reference Type:

publication

Title:

Correlation between the levels of certain carcinogenic and anticarcinogenic trace elements and esophageal cancer in Northern Iran.

Author:

Azin F; Raie RM; Mahmoudi MM

Year:

1998

Bibliographic source:

Ecotoxicol. Environ. Saf. 39, 179-184

Materials and methods

Endpoint addressed:

carcinogenicity

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Levels of four anticarcinogenic trace elements (Zn, Se, Mn, Mg) were measured in hair samples from oesophageal cancer patients, their unaffected family members, and members of families with no history of cancer. Measurements were also made in non-oesophageal cancer patients, using atomic absorption spectroscopy, inductively coupled plasma-emission spectroscopy, and neutron activation analysis.

Test material

Test material information

Constituent 1

Reference substance name:

not defined

IUPAC Name:

not defined

Method

Subjects:

Levels of four anticarcinogenic trace elements (Zn, Se, Mn, Mg) were measured in hair samples from esophageal caner patients, their unaffected family members, and members of families with no history of cancer. Measurements were also made in non-esophageal cancer patients, using atomic absorption spectroscopy, inductively coupled plasma-emission spectroscopy, and neutron activiation analysis.

Results and discussion

Results of examinations:

According to ATSDR expert judgement, the study revealed no association between selenium intake and incidence of cancer. For selenium, the results of the study showed that the levels were not significantly different in the above mentioned groups.

Any other information on results incl. tables

For selenium, the results showed that the levels were not significantely different in the above mentioned groups.

Applicant's summary and conclusion

Conclusions:

According to ATSDR expert judgement, the study revealed no association between selenium intake and incidence of cancer. Levels of four anticarcinogenic trace elements (Zn, Se, Mn, Mg) were measured in hair samples from esophageal caner patients, their unaffected family members, and members of families with no history of cancer. Measurements were also made in non-esophageal cancer patients, using atomic absorption spectroscopy, inductively coupled plasma-emission spectroscopy, and neutron activiation analysis. For selenium, the results showed that the levels were not significantely different in the above mentioned groups.