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EC number: 237-048-9 | CAS number: 13597-46-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- other: human case control study
- Adequacy of study:
- supporting study
- Reliability:
- other: Not rated. No significant deficiencies in study design and evaluation were reported by ATSDR, 2003 expert judgment.
- Rationale for reliability incl. deficiencies:
- other: No significant deficiencies in study design and evaluation were reported by ATSDR, 2003 expert judgment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Serum levels of selenium and retinol and the subsequent risk of cancer.
- Author:
- Coates, RJ; et al.
- Year:
- 1 988
- Bibliographic source:
- Am J Epidemiol 128:515-523
Materials and methods
- Endpoint addressed:
- carcinogenicity
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A nested case-control study was conducted to assess the relation between serum levels of selenium and retinol and the subsequent risk of cancer. During the years 1972-1984, in northwest Washington State, 156 cases of cancer were identified among members of two employee cohorts from whom specisms had been previously obtained and stored. 287 controls were selected from these cohorts and matched to cases on the basis of employer, age, sex, race, and date of blood draw. Selenium and retinol levels were measured by neutron activation and high pressure liquid chromatography, respectively. Information on known cancer risk factors were collected by telephone interviews of the subjects and next of kin.
Test material
- Reference substance name:
- not defined
- IUPAC Name:
- not defined
Constituent 1
Method
- Details on study design:
- A nested case-control study was conducted to assess the relation between serum levels of selenium and retinol and the subsequent risk of cancer. During the years 1972-1984, in northwest Washington State, 156 cases of cancer were identified among members of two employee cohorts from whom specisms had been previously obtained and stored. 287 controls were selected from these cohorts and matched to cases on the basis of employer, age, sex, race, and date of blood draw. Selenium and retinol levels were measured by neutron activation and high pressure liquid chomatography, respectively. Information on known cancer risk factors were collected by telephone interviews of the subjects and next of kin.
Results and discussion
- Results:
- According to ATSDR expert judgement, the study revealed no association between selenium intake and incidence of cancer. A nested case-control study was conducted to assess the relation between serum levels of selenium and retinol and the subsequent risk of cancer. The findings of this study suggest that neither serum levels of selenium nor those of retinol have an appreciable effect on the risk of cancer.
Any other information on results incl. tables
Levels of selenium and retinol were unassociated with the incidence of cancer of all sites combined, both overall and within subgroups defined by age, sex, levels of the other micronutrient, time between blood draw and diagnosis, smoking status, and family history of cancer. These findings suggest that neither serum levels of selenium nor those of retinol have an appreciable effect on the risk of cancer.
Applicant's summary and conclusion
- Conclusions:
- According to ATSDR expert judgement, the study revealed no association between selenium intake and incidence of cancer. A nested case-control study was conducted to assess the relation between serum levels of selenium and retinol and the subsequent risk of cancer. The findings of this study suggest that neither serum levels of selenium nor those of retinol have an appreciable effect on the risk of cancer.
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