Registration Dossier
Registration Dossier
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EC number: 231-974-7 | CAS number: 7783-00-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
An evaluation of toxicokinetic information is available from a renown scientific body (ATSDR, 2003) on selenium and selenium compounds. Two publications are available on toxicokinetic behaviour of selenous acid which are considered reliable data:
(i) Furchner et al. (1975) estimated that over 90% of an oral dose of selenious acid was absorbed in mice and dogs, although monkeys absorbed less of the administered dose (amount unspecified).
(ii) Weissman (1983): It is reported that selenium concentrated in the liver, kidney, spleen, and lungs of dogs following inhalation exposure to selenous acid. According to ATSDR (2003), the study indicates that absorption of selenium following inhalation exposure is extensive, although the rate of absorption depends on the chemical form of selenium. The absorption of selenium following inhalation exposure to selenious acid aerosol is approximately twice as rapid as the absorption of selenium following inhalation exposure to elemental selenium aerosol.
Reference:
ATSDR (2003). Agency for toxic substances and disease registry. Toxicological profile for selenium. U.S. Department of Health and Human Services, Public Health Services, Atlanta, Georgia.
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