Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-866-0
CAS number: 498-66-8
Norbornene was tested in a reverse gene mutation assay (Ames test) in
bacteria (S. typhimuriumTA98; TA 100; TA1535; TA1537) in concentrations
ranging from 0 to 5000 µg/plate in the presence and absense of mammalian
metabolic activation (S9 mix induced from rat liver). The study was
performed according to OECD 471 under GLP.
there was no evidence of induced mutant colonies over background.
Cytotoxicity was obsevered with TA 100 at the highest concentrations of
2500 and 5000 µg/plate.
In a first study (W. Müller, 1995) norbornene was assessed for its
mutagenic potential in vitro in the chromosomal aberrationtest with two
independant experiments with and without metabolic activation. No
relevant reproducible enhancement of metaphases with aberrations over
the range f the solvent control was found at any of the used
concentrations. Cyctotoxicity was observed above 100 µg/ml.
In a second supporting study (A.Czich, 1997) again no increased,
biologically relevant frequency of cells with structural chromosomal
aberrations or polyploid metaphases could be observed. Cytotoxicity set
in at and above concentrations of 150 µg/ml.
2 -Norbornene was tested in the intro HGPRT gene mutation assay with the
V79 Chinese hamster cell line with and without metabolic activation. The
test was carried out at dose levels from 10 -150 µg/ml, at higher dose
levels strong cytotoxicity had been observed.
no effects judged to be of biological relevance were observed, the
substance did not induce gene mutations under the experimental
no indication of gene-toxicity in any of the tests.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again