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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable publication which meets basic scientic principles; basic data on expermimental design are given.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VII
Author:
Smyth, HF; Carpenter, CP; Weil, CS; Pozzani UC; Striegel JA; Nycum, JS
Year:
1969
Bibliographic source:
Amer. Ind. Hyg. Assoc. J. 30 (1969), 470
Report date:
1969
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth, HF; Carpenter, CP; Weil, CS; Pozzani UC; Striegel JA
Year:
1962
Bibliographic source:
Amer. Ind. Hyg. Assoc. J. 23 (1962), 95
Report date:
1962

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
non-fasted animals, limited reporting
GLP compliance:
no
Remarks:
pre-GLP study
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
8,9,10-trinorborn-2-ene
EC Number:
207-866-0
EC Name:
8,9,10-trinorborn-2-ene
Cas Number:
498-66-8
Molecular formula:
C7H10
IUPAC Name:
Bicyclo-[2.2.1]-hept-2-ene
Details on test material:
- name of test material as cited in study report: 2-Norbornene
- no further information on test substance

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Test Animals
Source: no data
Weight at initiation of study: 90-120 g
Age: 4-5 weeks
No fasting before commencement of study
housing: no data
acclimatation: no data
Diet and Water ad libidum

environmental conditions:
no data on humidity, temperature, airchange or lightning conditions.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
At least 4 dose levels in a logarithmic scale differing by a factor of 2. Individual doses not specified
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
observation period following administration:14d (no data on frequency and weighing)
examinations performed: no data
Necropsy performed: no data

Statistics:
LD50 values were calculated according to the method of Thompson (1947, Bacteriol. Rev. 11, 115) using the tables of Weil. (1952, Biometrics 8, 249).
The limits of +/- 1.96 standard deviations are presented.

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
11 mL/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
9 577 mg/kg bw

Any other information on results incl. tables

Fiducial range of LD50 (presented as +/- 1.96 standard deviations) was 7.0 - 18.3 ml/kg b.w. corresponding to 6094 - 1593 mg/kg b.w.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 of Norbornene was determined to be 11 ml/kg b.w. corresponding to 9577 mg/kg b.w.
Executive summary:

The acute oral toxicity of Norbornene was determined in groups of 5 male Carworth-Wistar rats, each receiving an oral dose of the test substance by gavage. Dosage range was spaced in a logarithmic spacing of a factor 2. The observation period was 14d. The LD50 was determined with a range of +/-1.96 standard deviations according to the calculation method of Thomson (1947). Overall the study was conducted similar to OECD 401 (retracted)

The acute oral LD50 was 9577 mg/kg b.w. in male rats (Smyth, 1969)