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EC number: 204-278-6 | CAS number: 118-79-6
Five rats/gender/dose were repeatedly exposed for 21 days (15 doses total) to 2,4,6 -tribromophenol dust in individual whole-body inhalation chambers. The doses were 0, 0.1, and 1.0 mg/l clean, dry air, and the exposure was for 6 hours/day, 5 days/week. Data was taken for physical reactions from dosing, body weight, maematology, clinical chemistry, urinalysis, gross pathology, and histopathology. There was one low dose male and one high dose female that died after 10 and 11 doses, respectively. Animals in both treatment groups exhibited hypoactivity, salivation, lacrimation, and red nasal discharge during testing. Hypoactivity, lacrimation, and nasal discharge are symptoms consistent with exposure to dust particulates without regard to the compound itself. Salivation has been noted as a transient symptom after exposure to tribromophenol specifically. Low dose animals showed similar weight gain to controls, but high dose animals exhibited visibly lower weight gain than controls. Additionally, dilation of renal tubules was seen in 3 of 5 high dose animals of both genders, and one high dose female had two liver lesions (submassive necrosis and fibrosis).
Based on the above observations, the NOAEL is set at 0.1 mg/l (transient salivation is not considered adverse), and the LOAEL is set at 1.0 mg/l. This study is considered adequate to determine target organs and order of magnitude to find effects, but does not meet current standards for study design or documentation of results. This dose is also expected to be inaccurate based on oral exposure from grooming during and after the whole-body exposure in the inhalation chamber.
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