Registration Dossier
Registration Dossier
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EC number: 245-883-5 | CAS number: 23783-42-8
Endpoint summary
Administrative data
Description of key information
Multiple studies available indicating results from no irritancy to slight skin irritancy.
Multiple studies available indicating results from no irritancy to slight eye irritancy (mild conjunctival redness only, resolved within 72 hours)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A number of valid skin irritation studies are available using the substances methyl triglycol and methyl tetraglycol and mixtures containing significant amounts of these substances. The majority of the animal studies using rabbits indicate no irritation response, although some indicate transient response, primarily erythema with no odema seen.
A number of valid eye irritation studies are available using the substances methyl triglycol and methyl tetraglycol and mixtures containing significant amounts of these substances. These show consistent results with no observable iritis, corneal effects or chemosis observed at any observation point. The only observed effect is mild to moderate transient conjunctival redness (maximum observed value in any animal score 2, with average values in the range 0 to 0.6). These effects are consistently resolved within 72 hours.
Justification for classification or non-classification
SKIN IRRITATION: Of those studies available that provide sufficient information to compare to the classification criteria, the data indicate that the response required to trigger classification for acute skin irritation effects is not met and classification is clearly not required.
EYE IRRITATION: Of those studies available that provide sufficient information to compare to the classification criteria, the data indicate that the response required to trigger classification for acute skin irritation effects is not met. Only mild and transient conjunctival redness is seen and this effect normally resolves within 72 hours or less. Classification is clearly not required.
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