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EC number: 232-140-5 | CAS number: 7789-00-6
The results of the micronucleus tests conducted in three strains of mice were variable:
Micronucleus frequencies were determined in peripheral blood erythrocytes of male and female B6C3F1 mice administered sodium dichromate dihydrate over an exposure concentration range of 62.5 to 1000 mg/L for 3 months. No significant increases were seen in micronucleated normochromatic erythrocytes in male or female mice over the exposure concentration range tested; there was a decrease in the percentage of polychromatic erythrocytes among total erythrocytes (an indication of bone marrow toxicity), but the changes were small and did not clearly correlate with exposure concentration.
Micronucleus frequencies were evaluated in male B6C3F1, BALB/c, and am3 -C57BL/6 mice administered sodium dichromate dihydrate over an exposure concentration range of 62.5 to 250 mg/L in drinking water for 3 months. An increase in micronucleated erythrocytes that was judged to be equivocal was noted in male B6C3F1 mice, based on the trend test (P=0.031), which showed an increase in micronucleated normochromatic erythrocytes that did not reach statistical significance (required P value of 0.025); no exposed groups were significantly increased over the control group in this study. No increase in micronucleated normochromatic erythrocytes was observed in male BALB/c mice (Table B4). A significant exposure concentration-related increase (P<0.001) in micronucleated erythrocytes was noted in male am3-C57BL/6 mice (Table B5). In this study, two of three dose groups were significantly (P<0.008) elevated over the control group. No significant effect of chemical exposure on the percentage of polychromatic erythrocytes was observed in any of the three micronucleus tests conducted in study 2.
Micronucleated NCEs (/1000)
*significant by the trend test
The potenital of sodium dichromate to induce micronuclei was investigated in the peripheral blood erythrocytes of three strains of mice following administration via drinking water for 3 months. A significant increase in the frequency of micronuclei was seen in the transgenic am3 -C57/BL6 strain, however similar findings were not apparent in B6C3F1 of BALB/c mice. The results of this study are therefore equivocal.
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