Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-140-5 | CAS number: 7789-00-6
Groups of rats (5/sex) were gavaged with single doses of sodium chromate, sodium dichromate or potassium dichromate (in water) at dose levels of between 10 and 300 mg/kg bw. Animals were observed for 14 days. Bodyweights were recorded on Days 1, 4, 7, 11 and 14. Gross necropsy was performed on all animals and organ weights recorded.
Deaths occurred at dose levels of >=75 mg/kg bw (sodium chromate, sodium, dichromate) and at >=100 mg/kg bw (potassium dichromate): females were slightly more sensitive than males for all compounds. Signs of toxicity were observed in all groups and included hunched posture, tremors, hypokinesia, sedation, prostration, coma, piloerection, ataxia, diarrhoea, dacryorrhoea and hyperkinesia. Slightly reduced weight gain was seen in some surviving animals. Findings at necropsy were limited to reddening and staining of the stomach, abnormal gastric contents and green staining of the lungs. Organ weights were unaffected by treatment.
LD 50 values were calculated to be:
Sodium chromate: 129.5 (118.5 -142.0) mg/kg bw in males; 67.0 (58.5 -77.0) mg/kg bw in females
Sodium dichromate: 123.5 (107.0 -142.5) mg/kg bw in males; 86.5 (74.0 -101.0) mg/kg bw in females
Potassium dichromate: 168.0 (154.5 -182.5) mg/kg bw in males; 90.5 (81.5 -100.5) mg/kg bw in females
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again