Potassium chromate

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

Not applicable

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Thresholds for induction are not reported and quantitative extrapolation to all substances in the group is not possible

Data source

Reference

Reference Type:

other: EU RAR

Title:

European Union Risk Assessment Report

Author:

European Chemicals Bureau

Bibliographic source:

3rd Priority List, Volume 53

Materials and methods

Type of sensitisation studied:

skin

Study type:

other: Review

Test guideline

Qualifier:

no guideline followed

Deviations:

not specified

Principles of method if other than guideline:

Reports of clinical cases and patch-testing studies of various designs.

GLP compliance:

no

Remarks:

Not applicable

Test material

Test material information

Constituent 1

Reference substance name:

Sodium dichromate

EC Number:

234-190-3

EC Name:

Sodium dichromate

Cas Number:

10588-01-9

Molecular formula:

Cr2Na2O7

IUPAC Name:

sodium dichromate

Constituent 2

Reference substance name:

Potassium dichromate

EC Number:

231-906-6

EC Name:

Potassium dichromate

Cas Number:

7778-50-9

Molecular formula:

Cr2H2O7.2K

IUPAC Name:

sodium dichromate

Details on test material:

The EU RAR covers the water soluble Cr (VI) compounds chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate and
potassium dichromate. Patch testing was carried out mainly using sodium or potassium dichromate, however the results can be qualitatively
extrapolated to the other compounds in this group.

Method

Type of population:

other: general and occupational

Controls:

Not reported.

Route of administration:

dermal

Results and discussion

Results of examinations:

See discussion below.

Any other information on results incl. tables

Concentrations of 0.5% and below of aqueous potassium dichromate have been reported to elicit positive responses in patch testing studies. In one study, a minimum (10% reacting) elicitation concentration of 0.09 µg Cr(VI)/cm2 was calculated after 54 Cr(VI)-sensitive volunteers were exposed to potassium dichromate.

Applicant's summary and conclusion

Conclusions:

The results of patch testing studies reported in the EU RAR indicate that the water-soluble Cr (VI) compounds in this group are capable of causing skin sensitisation follwoing occupational exposure.

Executive summary:

Allergic contact dermatitis (skin sensitisation) resulting from occupational exposure to water soluble Cr (VI) compounds is commonly encountered in a number of different groups. The EU RAR has reviewed a number of published reports of patch testing in Cr (VI) sensitised humans; the studies report minimum eliciting concentrations as low as 0.09 ug Cr (VI) /cm2. The majority of reported studies were performed using aqueous solutions of sodium or potassium dichromate; while similar effects can be assumed for other water-soluble Cr (VI) compounds, a similar concentration-response relationship cannot be assumed as this will also be influenced by the extent of dermal penetration.