Registration Dossier
Registration Dossier
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EC number: 231-106-7 | CAS number: 7439-97-6
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Exposure related observation in humans
- Adequacy of study:
- weight of evidence
- Study period:
- no data available
- Reliability:
- other: relevant
- Rationale for reliability incl. deficiencies:
- other: Well documeted publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Elemental mercury exposure in early pregnancy.
- Author:
- Thorp, J.M.; et al.
- Year:
- 1 992
- Bibliographic source:
- Obstet. Gynecol. May. 79 5 ( Pt 2): 874-6.
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- toxicity to reproduction / fertility
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Case study: 29 years old married white woman pregnant in the first trimester was exposed mercury vapour concentrations in their home of 20-60 µg/m³ (much higher than the EPA ambient air conc. of 1 µg/m3) from mercury spilled into the carpets.
- GLP compliance:
- no
Test material
- Reference substance name:
- Mercury
- EC Number:
- 231-106-7
- EC Name:
- Mercury
- Cas Number:
- 7439-97-6
- Molecular formula:
- Hg
- IUPAC Name:
- mercury
- Details on test material:
- - Name of test material (as cited in study report): mercury vapour (not further specified)
- Molecular formula (if other than submission substance): Hg
No further details are given.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 1
- Sex: female
- Age: 29 years
- Race: white woman - Ethical approval:
- not specified
- Route of exposure:
- inhalation
- Reason of exposure:
- accidental
- Exposure assessment:
- not specified
- Details on exposure:
- no data
- Examinations:
- - Urine analysis: yes; mercury levels in unrine were determined
- Haematology: no data
- Lung function parameters: no data
- Other: neurologic examinations: no further details - Medical treatment:
- no data
Results and discussion
- Clinical signs:
- The woman did not show any signs of intoxication and neurological examination was normal.
- Results of examinations:
- The 24-h urinary Hg levels were elevated to 230 µg/L. Urinary mercury declined through gestation from 7.5 µg/L (24 weeks) to 2.7 µg/L (33 wks) and levels not detectable at week 36.
The woman laboured spontaneously a healthy child which grew up appropriately until the age of 2 years and met all developmental milestones. - Effectivity of medical treatment:
- no details
- Outcome of incidence:
- no data
Applicant's summary and conclusion
- Conclusions:
- A woman exposed accidentally to mercury vapour did not show any signs of intoxication and neurological examination was normal. Study not appropriate to set NOAEL/LOAELs.
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