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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from publication containing range finding results

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: see Principles of method if other than guideline
Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publication in Am. J. Ophthalmol. 29, 1363-1372 (1946).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
cis-3,5,5-trimethylcyclohexan-1-ol
EC Number:
213-268-0
EC Name:
cis-3,5,5-trimethylcyclohexan-1-ol
Cas Number:
933-48-2
Molecular formula:
C9H18O
IUPAC Name:
(1R,5R)-3,3,5-trimethylcyclohexan-1-ol
Details on test material:
Test substance: other TS: 3,3,5-Trimethylcyclohexanol, no further data; no further information about the isomeric ratio

Test animals

Species:
rabbit

Test system

Type of coverage:
open
Vehicle:
other: initially none; acetone for dilution series of corrosive substances
Amount / concentration applied:
undiluted total volume applied : 0.01 ml
Duration of treatment / exposure:
24 hour(s)
Observation period:
24 hours after exposure
Number of animals:
5

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 h
Score:
5
Max. score:
10
Reversibility:
no data
Remarks on result:
other: strong erythema, edema, or slight necrosis

Any other information on results incl. tables

Irritation index: 5 (= strong erythema, edema, or slight necrosis)

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
In a range finding studies with rabbits the skin irritation was determined at a scaling of 5 out of 10. The study is used as key study.
Executive summary:

In a range finding studies with rabbits the skin irritation was determined at a scaling of 5 out of 10.

Strong erythema, edema or light necrosis were observed. Based on the results the substance is considered to be irritant to skin. The study is used as key study.