Registration Dossier
Registration Dossier
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EC number: 213-268-0 | CAS number: 933-48-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data, list III
- Author:
- Smyth H.F. ; Carpenter C.P.; Weil C.S.
- Year:
- 1 949
- Bibliographic source:
- The Journal of Industrial Hygiene and Toxicolology, 31(1), 60-62
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see Principles of method if other than guideline
- Principles of method if other than guideline:
- Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- EC Number:
- 213-268-0
- EC Name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- Cas Number:
- 933-48-2
- Molecular formula:
- C9H18O
- IUPAC Name:
- (1R,5R)-3,3,5-trimethylcyclohexan-1-ol
- Test material form:
- not specified
- Details on test material:
- Test substance: 3,3,5-Trimethylcyclohexanol, no further data no further information about the isomeric ratio
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- four doses in a geometrical series
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 250 mg/kg bw
Any other information on results incl. tables
Confidence interval ("fiducial range"): 2740 - 3860 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- An acute oral toxicity LD50 for male rats of 3250 mg/kg (CI 2740 - 3860 mg/kg bw) was obtained in a published study from 1949. The study is taken as key study for the asssessment.
- Executive summary:
The LD50 for acute oral toxicity in male rats is 3250 mg/kg (CI 2740 - 3860 mg/kg bw) as published in the study from Smyth et al. (1949) for the substance 3,3,5-Trimethylcyclohexanol . The study is taken as key study for the asssessment.
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