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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute toxicity: oral: LD50 = 3250 mg/kg bw (WoE).
Acute toxicity: dermal: LD50 = 2430 mg/kg bw ( WoE).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
Qualifier:
according to guideline
Guideline:
other: see Principles of method if other than guideline
Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Sherman
Sex:
male
Route of administration:
oral: gavage
Vehicle:
water
Doses:
four doses in a geometrical series
No. of animals per sex per dose:
5
Sex:
male
Dose descriptor:
LD50
Effect level:
3 250 mg/kg bw

Confidence interval ("fiducial range"): 2740 - 3860 mg/kg bw

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
An acute oral toxicity LD50 for male rats of 3250 mg/kg (CI 2740 - 3860 mg/kg bw) was obtained in a published study from 1949. The study is taken as key study for the asssessment.
Executive summary:

The LD50 for acute oral toxicity in male rats is 3250 mg/kg (CI 2740 - 3860 mg/kg bw) as published in the study from Smyth et al. (1949) for the substance 3,3,5-Trimethylcyclohexanol . The study is taken as key study for the asssessment.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
3 250 mg/kg bw
Quality of whole database:
Reliable with restrictions (Klimisch Code 2)

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
Qualifier:
according to guideline
Guideline:
other: see Principles of method if other than guideline
Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no
Test type:
standard acute method
Species:
rabbit
Type of coverage:
occlusive
Vehicle:
other: none (i.e. undiluted test substance)
Doses:
four dosages in a geometrical series
No. of animals per sex per dose:
5
Dose descriptor:
LD50
Effect level:
2 430 mg/kg bw

LD50 reported as 2.8 ml/kg bw

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
A dermal study with rabbits applying the test substance in four doses yields a LD50 reported as 2.8 ml/kg bw. The study was taken as key study for 3,3,5-trimethylcyclohexanole.
Executive summary:

A LD50 was reported for acute dermal toxicity as 2.8 ml/kg bw for the test substance in rabbits. The study was taken as key study for 3,3,5-trimethylcyclohexanol.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 430 mg/kg bw
Quality of whole database:
Reliable with restrictions (Klimisch Code 2)

Additional information

An acute oral toxicity LD50 for male rats of 3250 mg/kg (CI 2740 - 3860 mg/kg bw) was obtained in a published study from 1949. The study is taken as key study for the asssessment.

A dermal study with rabbits applying the test substance in four doses yields a LD50 reported as 2.8 ml/kg bw. The study was taken as key study for 3,3,5-trimethylcyclohexanole.


Justification for selection of acute toxicity – oral endpoint
Data from handbook or collection of data, important study details and confidence interval given, considered reliable.

Justification for selection of acute toxicity – dermal endpoint
Data from handbook or collection of data, important study details and confidence interval given, considered reliable.

Justification for classification or non-classification

Based on the available acute toxicity results in rodents the substance does not need to be classified for acute toxicity under EC 1272/2008 or the dangerous substance directive 548/67/EEC.