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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
no data
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliable with restrictions; similar to Federal Register guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 52 FR 42964; U.S. Department of Transportation
Principles of method if other than guideline:
52 FR 42964
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rabbit
Strain:
other: Albino

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5g at 3 test sites, corresponding to three exposure periods
Duration of treatment / exposure:
3 minutes, 60 minutes, 4 hours
Observation period:
48 hours
Number of animals:
6
Details on study design:
After the initial reading, the test sites were washed with USP Sterile Water for Injection to prevent further exposure. After the exposure period, the patches were removed and the resulting reactions scored for erythema, edema and/or corrosion. Readings were made again at the end of 48 hours.

Results and discussion

In vivo

Results
Irritation parameter:
other: qualitative assessment of corrosion
Basis:
mean
Time point:
other: 48 h
Remarks on result:
other: qualitative assessment for skin corrosion
Irritant / corrosive response data:
None of the animals exhibited any signs of skin corrosion at any of the test sites.

Any other information on results incl. tables

This is a qualitative test according to U.S. Department of Transportation guidelines. None of the animals exhibited any signs of skin corrosion at any of the test sites.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: other: U.S. Department of Transportation guidelines
Conclusions:
3-Cyanopyridine is not considered corrosive to the skin of albino rabbits after occlusive dermal exposure for 3 min, 1 hour and 4 hours.