Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Estimated using a validate QSAR model, ECOSAR, from the U.S. Environmental Protection Agency

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Validated QSAR modeling program, ECOSAR, part of the the U.S. EPA's EPISuite
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test organisms

Test organisms (species):
other: green algae

Study design

Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Test conditions

Reference substance (positive control):
no

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
232.153 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
not specified

Any other information on results incl. tables

                                                                   Predicted

ECOSAR Class                Organism           Duration End Pt  mg/L (ppm)

=========================== ================== ======== ======  ==========

Neutral Organics          : Fish               96-hr    LC50    2264.206

Neutral Organics          : Fish               14-day   LC50    2229.341

Neutral Organics          : Daphnid            48-hr    LC50    1000.650

Neutral Organics          : Green Algae        96-hr    EC50     232.153

Neutral Organics          : Fish               30-day   ChV      211.225

Neutral Organics          : Daphnid                      ChV       89.344

Neutral Organics          : Green Algae                  ChV       67.394

Neutral Organics          : Fish (SW)         96-hr    LC50    3567.931

Neutral Organics          : Mysid Shrimp       96-hr    LC50    7318.486

Neutral Organics          : Fish (SW)                   ChV      127.865

Neutral Organics          : Mysid Shrimp (SW)            ChV     1031.058

Neutral Organics          : Earthworm          14-day   LC50     268.318

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Remarks:
not a guideline study
Conclusions:
3-Cyanopyridine is predicted by ECOSAR (EPISuite 4.0) to have an EC50 in green algae of 232 mg/L.