Registration Dossier
Registration Dossier
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EC number: 403-030-6 | CAS number: 137398-54-0 ROBAC AS/100
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Acute and sub-acute studies have shown evidence that the
notified substance, AS-100 is absorbed following oral
administration in the rat. Absorption of the notified
substance has resulted in clinical signs of toxicity with
the principle target organ being the liver.
Changes in clinical chemistry parameters in the 28-day study
suggest that AS-100 has caused injury in this organ at
levels >12 mg/kg/day. Metabolism in the liver and
subsequent Phase II conjugation might be expected to result
in the major excretion route being via the faeces.
Effects were also seen in the red blood cells indicating
some initial binding of AS-100 may have occurred. Other
clinical signs of toxicity were noted in the spleen.
AS-100 is a lipophilic substance with an octanol-water
partition coefficient of 5.9 providing initial indications
at least that this substance may bioaccumulate in the fatty
tissues within the body.
The results of a sub-chronic study (90 day oral repeat dose) also showed evidence that the substance is absorbed following oral administration.
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