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EC number: 200-453-6 | CAS number: 60-09-3
Numerous patient cohorts and occupationally exposed persons clearly reacted positively to 4-Aminoazobenzene in concentrations of 0.25 - 2 % in vaseline or methylethylketone in the epicutaneous test. Moreover, several case descriptions exist in which positive reactions by 4-Aminoazobenzene in concentrations of 0.25 - 5 % could be triggered in individuals with dermatitis (Conde-Salazar et al., 1995; Kousa and Soini, 1980; BUA, 1998). No animal study with relevance for evaluation exists.
Based on human evidence of postive skin reactions, positive structural alert for skin sensitisation (aromatic amine) as well as classification of structurally related substances (i.e. aniline) classification of 4 -aminoazobenzene as skin sensitizer according to both Annex VI to 67/548/EEC and Annex I to the CLP-regulation is warranted.
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