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EC number: 406-640-0 | CAS number: 136920-07-5 KEROFLUX ES 3241
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Toxicokinetic in vitro
Incubation in 0.1 M HCl, rat plasma or rat liver homogenate at 37°C for up to 4 hours: no detectable formation of EDTA (GLP; BASF 1995)
Considerations based on physico-chemical properties
- inhalative exposure is considered as unlikely
- potential for a dermal absorption is considered as very low
- very low bioaccumulation potential is assumed
Key value for chemical safety assessment
Additional information
In a toxicokinetic study according to GLP requirements, the degradation of the test substance Keroflux ES 3241 and the formation of EDTA was determined after incubation either in 0.1 M HCl, rat plasma or rat liver homogenate in order to simulate conditions in stomach, blood and liver (BASF AG 1995).
Incubation of Keroflux ES 3241 in 0.1 M HCl 1 mg/ml at 37°C for up to 4 hours simulating conditions in the stomach lead to a small decrease of Keroflux ES 3241 concentration in the incubation medium (maximum 6% after 4 hrs of incubation). With respect to the variation of the results at 1 and 2 h, this decrease is not significant. No EDTA could be detected considering a detection limit of about 2 µg/ml.
Incubation of Keroflux ES 3241 in rat plasma at 37°C for up to 4 hours lead to a decrease of Keroflux ES 3241 concentration in the incubation medium by 24 % after 4 hrs of incubation (10% after 2 hrs of incubation). However, no EDTA could be detected above a detection limit of about 2 µg/ml.
Considerations based on physico-chemical properties:
Keroflux ES 3241 has a very low vapour pressure (< 0.0006 Pa at 20°C, see IUCLID chapter 4.6), therefore an inhalative exposure is considered as unlikely. Additionally, the potential for a dermal absorption is considered as very low due to the high molecular weight (between 1630 and 2310 g/mol) and the low solubility in water and in octanol (see IUCLID chapter 4.7). Furthermore, a very low bioaccumulation potential is assumed based on a calculated log Pow range of 41 to 67 (see IUCLID chapter 5.3.1).
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