Registration Dossier
Registration Dossier
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EC number: 464-510-9 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 464-510-9
- EC Name:
- -
- Cas Number:
- 147768-39-6
- Molecular formula:
- C10H23O3P
- IUPAC Name:
- 3-[(3-hydroxypropyl)(2-methylpropyl)phosphoryl]propan-1-ol
- Test material form:
- liquid: viscous
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation system:
- Aroclor 1254 induced rat liver S9
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 50 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 50 ... 5000 µg/plate - Vehicle / solvent:
- Solvent: Sterile distilled water
Results and discussion
Test results
- Species / strain:
- other: all strains
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 µg/plate)
- Additional information on results:
- Observations:
The vehicle control plates produced counts of revertant colonies within the normal range.
All of the positive control chemicals used in the test
induced marked increases in the frequency of revertant
colonies, both with and without metabolic activation.
The test substance caused no visible reduction in the growth
of the bacterial lawn at any dose level either with or
without metabolic activation, it was, therefore, tested up
to the maximum recommended dose level of 5000 µg/plate.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results
negative with metabolic activation
negative without metabolic activation - Executive summary:
No clasification is required for the test item according to the Ames test performed.
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