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EC number: 439-840-1 | CAS number: 20846-91-7
No evidence of erythema or edema was observed after each of the three induction exposures or at 24 or 48 h following the challenge dose.
After a range-finding study to determine the concentrations of the test substance to use, groups of ten guinea pigs of each sex were exposed to a 50% solution of the test substance for 6 h under an occluded patch applied to the clipped shoulder region, followed by two further exposures at 7-day intervals. After a 2-week recovery period, the animals were exposed to a 50% challenge dose and observed for skin reactions for 48 h. Groups of five animals of each sex were used as negative controls, receiving only the challenge dose.
There was no evidence of positive skin reactions either after the induction exposures or after the challenge dose in any of the animals. No deaths occurred during the study and no clinical signs of toxicity or effects on body weight gain were seen.
In a modified Buehler assay, trisodium EDDS showed no sensitising potential to the skin of guinea pigs after induction by three weekly exposures to 50% of the test material followed two weeks later by a 50% challenge dose. According to EU CLP and DSD regulations, trisodium EDDS would not be classified as a skin sensitiser under the conditions of this test.
[Data on trisodium EDDS is considered relevant to use for understanding the sensitisation potential of EDDS acid, and is acceptable for using as read-across information.]
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