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EC number: 470-080-3
CAS number: -
was tested in a bioconcentration test to Zebrafish (Danio rerio) over an
uptake period of 14 days followed by a depuration period of 16 days
according to the US EPA Guideline, OPPTS 850.1730, the OECD-Guideline
305, 1996 and the MITI-Guideline to the Testing Methods for New
Chemical. The fish were exposed to the test concentrations 1.0 and 10
µg/L in a flow-through-system.14C-radio labaled test
substance was used.
During the exposure to the test substance no
toxic effects like mortality or changes in behavior or appearance were
observed in the test organisms.
During the depuration phase the half-life
time for the test substance in fish was 1.7 days in the low and 0.6 days
in the high concentration. Approximately 90% of the steady state
concentration of the test substance was excreted after 5.6 days in the
low concentration and after 1.8 days in the high concentration. This
indicates a fast depuration of the test substance from the organism.
The concentration in fish reached steady
state within 10 days in both concentration groups.
Based on the steady state concentrations the
bioconcentration factor BCFss determined in the two concentration groups
was 10.8 in the lower concentration and 8.6 in the higher concentration.
The uptake curve of both test groups was similar. The mean
bioconcentration factor was 9.7.
Based on kinetic modeling the
bioconcentration factor BCFk was 9.1 in the lower and 7.8 in the higher
concentration. The mean bioconcentration factor was 8.5.
In conclusion the bioconcentration factor
was 9.1 based on the mean of BCFss and BCFk. This value is based on
total radioactivity in the whole fish on wet weight basis.
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