Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 92/69/EWG, B.2; OECD 403
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
MMAD: 6,51 µm

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU (SPF)

Administration / exposure

Vehicle:
other: Luft "ENGLISH" Air
Details on inhalation exposure:
nose-only
Duration of exposure:
4 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 4.575 mg/L air
Exp. duration:
4 h
Mortality:
Male: 0 mg/L; Number of animals: 5; Number of deaths: 0
Male: 5 mg/L; Number of animals: 5; Number of deaths: 0
Female: 0 mg/L; Number of animals: 5; Number of deaths: 0
Female: 5 mg/L; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Mortality did not occur in any group. All rats tolerated the exposure without specific signs. Body weight development between the control and the exposure groups is not significantly influended by the test
Gross pathology:
Effects on organs:
Necropsy findings were not observable.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU