Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 84/449/EWG, B.1; OECD 401
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test animals

Species:
other: rat, Wistar Bor:(SPF-Cpb)

Administration / exposure

Vehicle:
other: Wasser; Suspension, unmittelbar vor der Behandlung formuliert. "ENGLISH" Water, suspension, formulated immediately prior to treatment.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Nach einmaliger Gabe der Dosierung von 2000 mg/kg wurde bei
allen männlichen Tieren von 15 Minuten bis 2 Stunden nach
der Applikation leicht gesträubtes Fell beobachtet.

Das Wachstum wurde nicht beeinflusst.

"ENGLISH"

After single administration of the dose of 2000 mg/kg,
slight piloerection was observed in all of the male animals
between 15 minutes and 2 hours after application.

Growth was not influenced.
Gross pathology:
Effects on organs:
Alle am Versuchsende getöteten Tiere waren
pathologisch-anatomisch unaufällig.

"ENGLISH"

All of the animals killed at the end of the study were
pathologically-anatomically inconspicuous.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU