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EC number: 700-055-7 | CAS number: 630113-05-2
Vehicle: propylene glycol
Test item concentration % (w/v)
number of lymph nodes
DPM per lymph nodeb)
BG = Background (1 ml 5% trichloroacetic acid) in duplicate
1 = Control Group
2-5 = Test Group
S.I. = Stimulation Index
a) = The mean value was taken from the figures BG I and BG II
b) = Since the lymph nodes of the animals of a dose group were pooled, DPM/node was determined by dividing the measured value by the number of lymph nodes pooled
In this study the test item Triquat Monomer dissolved in propylene glycol was assessed for its possible contact allergenic potential.
For this purpose a local lymph node assay was performed using test item concentrations of 10, 25, 50, and 100%.
The animals did not show any clinical signs during the course of the study and no cases of mortality were observed. Local signs of irritation of the ear skin were not detected. Ear thickness or ear weights were not affected.
In this study Stimulation Indices (S.I.) of 0.93, 1.12, 0.72 and 1.42 were determined with the test item at concentrations of 10, 25, 50, and 100% in propylene glycol, respectively. The test item was not a skin sensitiser in this assay under the described conditions.
Triquat Monomer is not classified as a skin sensitiser according to the criteria of Annex VI Directive 67/548/EEC and EU GHS.
Concentrations of 10, 25, 50% in propylene glycol and the substance applied neat induced no increase of the SI above 3. The substance is not considered a sensitiser.
There is no data from human observation indicating respiratory sensitisation among the worker population in the plant.
Furthermore, no significant inhalation exposure is expected to the substance during manufacture and use, either as vapours or aerosols. The substance is expected to have a limited volatility potential (Vapour pressure estimated to be 3062 Pa at 25 degree C, boiling point of 106.4 degree Celsius). No cutaneous sensitisation was observed which would trigger an alert for respiratory sensitisation.
A reliable LLNA study showed no cutaneous sensitisation.
No classifiation due to the lack of data. There are no specific alerts. Also, no significant exposure is expected to aerosols or vapours during manufacture and use. There has been no report of observations in human.
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