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EC number: 700-055-7 | CAS number: 630113-05-2
Two in vitro studies for skin corrosion/irritation and one in vivo reliable study in rabbits showed no signs of skin irritation.One in vitro study and one in vivo study in rabbits showed no signs of irritation to the eyes.
The primary skin irritation potential of TRIQUAT Monomer was investigated according to OECD test guideline No. 404, Commission Regulation (EC) No. 440/2008, B.4. and Regulation (EC) No 1272/2008. The test item was applied by topical semi-occlusive application of 0.5 mL to the intact left flank of each of three young adult New Zealand White rabbits. The duration of treatment was four hours. The scoring of skin reactions was performed 1, 24, 48 and 72 hours after removal of the dressing.
The test item did not elicit any skin reactions at the application site of any animal at any of the observation times (all scores 0). The individual mean score for erythema/eschar and oedema for each of the three animals was therefore 0.
The test item did not cause any staining of the treated skin. No corrosive effects were noted on the treated skin of any animal at any of the measuring intervals and no clinical signs were observed.
The primary eye irritation potential of TRIQUAT Monomer was investigated according to OECD test guideline no. 405. The test item was applied by instillation of 0.1 mL into the left eye of each of three young adult New Zealand White rabbits. Scoring of irritation effects was performed approximately 1, 24, 48 and 72 hours after test item instillation.
The instillation of TRIQUAT Monomer into the eye resulted in mild, early-onset and transient ocular changes, such as conjunctival and scleral reddening as well as conjunctival chemosis in the male and one female.The conjunctival effects were no longer evident from 24 hours after treatment. The scleral reddening persisted in both animals at the 24 hours and in one of the two animals at the 48 hours. No abnormal findings were observed in the cornea or iris of any animal at any of the examinations. No corrosion was observed at any of the measuring intervals. No staining of the treated eyes by the test item was observed and no clinical signs were observed. One female was devoid of any local signs at any observation time.
Thus, the test item did not induce significant or irreversible damage to the rabbit eye.
The mean score was calculated across 3 scoring times (24, 48 and 72 hours after instillation) for each animal for corneal opacity, iris, redness and chemosis of the conjunctivae, separately. The individual mean scores for corneal opacity and iris were 0.00 for all three animals. The individual mean scores for the conjunctival reddening and chemosis were 0.00 for each of the
The in vivo studies conducted according to current standards showed no signs of irritation on contact with skin or eyes.
All the available experimental studies showed no signs of irritation to the skin and eyes. The substance is not classified according to EU criteria for classification (CLP Regulation 1272/2008 and EU Directive 67/548/EEC).
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