Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

LD50(rat), oral:   > 2000 mg/kg b.w.   (OECD 423 / EC B.1, GLP); limit test

Skin irritation:  irritating (OECD 404 / EC B.4, GLP)

Eye irritation:   A test according to EC method B.5 /OECD 405 (eye-irritation) was not performed, since the substance was irritating to the skin in undiluted form (EC method B.4/OECD 404). According to the EC method B.5 substances with known irritant or corrosive effects to the skin; should be considered to be irritating or corrosive, respectively, to the eyes as well. Therefore and for animal welfare, no test was performed and irritation to the eyes is assumed based on the outcome of the skin irritation study.

Skin sensitisation:  not sensitising (OECD 429 / EC B.42, GLP); LLNA

in vitro: Gene mutation (Bacterial reverse mutation assay / Ames test): S. typhimurium TA 1535, TA 1537, TA 98 and TA 100, TA102 negative with and without metabolic activation; Concentration range in the main test (experiment I: 3, 10, 33, 100, 333, 1000, 2500 and 5000 µg/plate and experiment II: 1, 3, 10, 33, 100, 333 and 1000 µg/plate, according to OECD 471.