Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

First-aid measures

Emergency measure - Inhalation: Remove to fresh air. If any trouble breathing, get immediate

medical attention. Administer artificial respiration if

breathing has ceased. If irritation or symptoms occur or

persist, consult a physician.

Emergency measure - Eyes: In case of eye contact, immediately rinse eyes thoroughly

with plenty of water. If wearing contact lenses, remove only

after initial rinse, and continue rinsing eyes for at

least 15 minutes. If irritation occurs or persists, consult

a physician.

Emergency measure - Skin: In case of skin contact, while wearing protective gloves,

carefully remove any contaminated clothing, including shoes,

and wash skin thoroughly with soap and water. If irritation

or symptoms occur or persist, consult a physician.

Emergency measure - Ingestion: Rinse mouth and drink a glass of water. Do not induce

vomiting unless under the direction of a qualified medical

professional or Poison Control Center. If symptoms persist,

consult a physician.

Fire-fighting measures

Recommended extinguishing agent: Carbon dioxide (CO2), extinguishing powder or water spray.

Product arising from burning: Combustion products may contain CO, CO2, and water.

Product determined by test: N

Protective equipment: Wear full protective clothing and self-contained breathing

apparatus.

Accidental release measures

Emergency measures in case of spillage: All spills should be handled according to site requirements.

In the case of liquids, use proper absorbent materials.

Forlaboratories and small-scale operations, incidental

spills within a hood or enclosure should be cleaned by using

a HEPA filtered vacuum or wet cleaning methods as

appropriate. For large dry or liquid spills or those spills

outside enclosure or hood, appropriate emergency response

personnel should be notified. In manufacturing and large-

scale operations, HEPA vacuuming prior to wet mopping or

cleaning is required.

Handling and storage

Handling: Observe usual precautions for handling chemicals. Ensure

adequate ventilation while handling the substance. Avoid

inhalation, contact with skin and eyes. Wear suitable

protective gloves and safety goggles. Wash thoroughly after

handling.

Schering-Plough Global Industrial Hygiene Services (GIHS)

has established standards for the Schering-Plough Industrial

Hygiene Risk Management (IHRM) Program to provide guidance

for protection of persons who handle Schering-Plough

materials, as well as materials purchased, for the research

and manufacture of Schering-Plough substances and

preparations.  This program is used at all Schering-Plough

facilities worldwide.  Key features of the IHRM include, but

are not limited to, Industrial Hygiene Risk Assessment

(IHRA) and Risk-Based Exposure Control Strategies (R-BECS).

IHRA is designed to evaluate each task or operation by

assessment of the hazard and potential degrees of exposure

to establish the actual risk of exposure by a worker

performing specific tasks.  The health hazard of a material

is determined by Schering-Plough Global Occupational &

Environmental Toxicology and is used as the 'hazard'

component of the two-dimensional model.  The hazard is

assessed against potential degrees of exposure that include

such elements as physical form of the substance, volume or

quantity used, duration and frequency of handling,  etc.

From this assessment, the use of the substance is classified

as a low to high exposure risk which is then used to

determine exposure control strategies, need for industrial

hygiene monitoring, and appropriate personal protective

equipment usage.  All personal protective equipment (PPE) is

chosen in accordance to local requirements and regulations

and is documented in the IHRA for that process.

The principles of the IHRA are communicated on Schering-

Plough Safety Data Sheets (SDSs) in appropriate sections

(e.g. section 8).  Because of the global use of the SDSs at

all Schering-Plough facilities, specifics for PPE are not

provided on the SDS.  Other operating procedures at each

site are used to communicate the use of appropriate PPE or

other handling guidance on a local level.  Specific

questions associated with health hazards, handling, and

disposal are handled by appropriate safety and environmental

professionals at each site or at the corporate level.

Storage: Store in well sealed and secure containers in adequate rooms

at room temperature. Avoid substance residues outside the

containers.

Packaging of the substance and or preparation: double polyethylene bags within fibre board drums;

25 - 150 kg

Transport information

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Marine transport (UN RTDG/IMDG)

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Air transport (UN RTDG/ICAO/IATA)

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Special provisions / remarks
Remarks:
Transport code: not classified.
Transport: Transport in well sealed suitable containers. The containers
should be secured against falling down. Label containers in
accordance with pertinent regulations.
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Exposure controls / personal protection

Stability and reactivity

Danger other than fire: none known.

Chemical reaction with water: not to be expected.

Dust explosion: Explosive mixtures with dust possible but not to be expected

if handled under good industrial hygiene practices.

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: The test item is designed for use in closed systems as an

intermediate in the synthesis of an active pharmaceutical

ingredient. Therefore it is expected that it will be

consumed in the processes where it is employed. Hence the

need for recovery / recycling of the substance does not

apply in this case.

Industry - Possibility of neutralisation: Not applicable.

Industry - Possibility of destruction: controlled discharge: Not suitable for disposal in waste water treatment plants.

Industry - Possibility of destruction - incineration: Incineration is the preferred method of disposal.

Industry - Possibility of destruction - water purification: Not applicable.

Industry - Possibility of destruction - other: None.

Public at large - Possibility of recovery/recycling: Not applicable.

Public at large - Possibility of neutralisation: Not applicable.

Public at large - Possibility of destruction: controlled discharge: Not applicable.

Public at large - Possibility of destruction - incineration: Not applicable.

Public at large - Possibility of destruction - water purification: Not applicable.

Public at large - Possibility of destruction - others: None.