Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 609-256-3 | CAS number: 365400-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 Jul 2003 - 09 Jan 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Study type:
- direct photolysis
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-2 (Photodegradation Studies in Water)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Canada PMRA DACO Number 8.2.3.3.2
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Analytical method:
- high-performance liquid chromatography
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0, 1, 3, 7 and 9 d post-application
- Sampling method: Two replicates were removed from the water bath at each interval for each label.
- Sampling methods for the volatile compounds, if any: Volatiles were not collected
- Sampling intervals/times for pH measurements: 0, 1, 3, 7 and 9 d post-application
- Sampling intervals/times for sterility check: 0, 1, 3, 7 and 9 d post-application
- Sample storage conditions before analysis: All samples were analyzed within 2 d of the sampling interval date
- Other observation, if any (e.g.: precipitation, color change etc.): none - Buffers:
- - pH: 7
- Type and final molarity of buffer: 0.01 M
- Composition of buffer: K2PO4 was dissolved in water (1.36 g per L) and the pH was adjusted to pH 7 by addition of 1 M potassium hydroxide. - Light source:
- Xenon lamp
- Light spectrum: wavelength in nm:
- < 290
- Details on light source:
- - Emission wavelength spectrum: < 290 nm
- Filters used and their purpose: Suprex (DSET) filter to limit emission wavelength to < 290 nm
- Light intensity at sample and area irradiated: 680 W/cm²
- Relative light intensity based on intensity of sunlight: Considering light intensity of an artificial light source calculated for 300-3000 nm, 58% of the light intensity is in the range of 300 to 800 nm.From the total radiant exposure measurement of 29.5 MJ/m², 17.1 MJ/m² was determined to be the daily irradiance (<800 nm) on June 23rd, 1988, in Phoenix, AZ (29.5 MJ/m² x 0.58 = 17.1 MJ/m²). Since the ozone layer effectively attenuates UV irradiation (< 290 nm) in the
atmosphere, and only the UV/visible absorption region is believed to be intense enough to drive photolytic reactions thus, the absorption region of interest is narrowed to 290-750 nm. The Suntest unit was operated at approximately 680 W/m2 (290-800 nm) to simulate highly photoreactive conditions. At this intensity it would take 7.0 hours in the Suntest unit to equal one solar day. Since 7.0 hours represents 1 environmental day, 212 hours of continuous irradiation at 680 W/m2 is equivalent to 30.3 environmental days (212 hours / 7.0 hours per day).
- Duration of light/darkness: Irradiated samples were continuously irradiated - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test apparatus/vessels: 20 mL quartz vessel
- Sterilisation method: 0.22 μm sterile filter (filtered after the addition of test substance); glassware was autoclaved
- Details of traps for volatile, if any: not performed
- If no traps were used, type of test system: closed system
- Indication of test material adsorbing to the walls of test apparatus: no
TEST MEDIUM
- Volume used/treatment: 20 mL
- Kind and purity of water: Purified with Milli-Q Gradient A10
- Preparation of test medium: A test solution with a concentration of 1 μg/mL was prepared as follows. An aliquot of [14C]-phenly labelled substance (315 μL, 40.0 μCi, 28.6 μCi/μMole) was obtained from the radiochemical repository. After solvent was removed from the solution by evaporation under a stream of nitrogen, the compound was re-dissolved in 500 mL of 0.01 M pH 7.0 buffer. The test substance concentration was determined by LSC (five aliquots of 100 μL).
A test solution with a concentration of 1 μg/mL was prepared as follows. An aliquot of [14C]-pyrazole labelled substance (540 μL, 76.7 μCi, 55.3 μCi/μMole) was obtained from the radiochemical repository. After solvent was removed from the solution by evaporation under a stream of nitrogen, the compound was re-dissolved in 500 mL of 0.01 M pH 7.0 buffer. The test substance concentration was determined by LSC (five aliquots of 100 μL).
REPLICATION
- No. of replicates (dark): 6
- No. of replicates (irradiated): 12 - Duration:
- 9 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.98 other: Pyrazole label: mg a.i./L
- Duration:
- 9 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.99 other: Phenyl label: mg a.i./L
- Reference substance:
- no
- Remarks:
- Reference standards were not used since limited degradation was observed
- Dark controls:
- yes
- Preliminary study:
- A preliminary study showed that no volatiles were generated; therefore no volatile traps were used in the study.
- Test performance:
- The test item did not degrade significantly in aqueous solution under continuous irradiation. Thus, no DT50 and DT90 values were determined.
- Parameter:
- max lambda
- Value:
- 290 nm
- % Degr.:
- 0.9
- Sampling time:
- 9 d
- Test condition:
- Dark samples
- Remarks on result:
- other: not determined
- Test condition:
- Irradiated samples
- Remarks on result:
- other: Half-lives of the test substance were not calculated due to limited degradation.
- Transformation products:
- no
- Remarks:
- No major transformation products were formed in this study. Minor degradates did not exceed 4.1% of the applied radioactivity.
- Details on results:
- HALF-LIFE
- Half-lives of the test substance were not calculated due to limited degradation.
TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
MAJOR TRANSFORMATION PRODUCTS (distinguish between dark and irradiated samples)
- No major transformation products were formed in this study.
MINOR TRANSFORMATION PRODUCTS (distinguish between dark and irradiated samples)
- Minor degradates did not exceed 4.1% of the applied radioactivity and were not determined - Validity criteria fulfilled:
- not applicable
Reference
Transformation of test item expressed as percentage of applied radioactivity (mean ± s.d.), in pH 7 buffer solution
|
Sampling Times [days] |
|||||
Day 0 |
Day 1 |
Day 3 |
Day 7 |
Day 9 |
||
Test item |
Irradiated |
100.0±0.1 |
99.9±0.0 |
97.7±2.6 |
99.9±0.4 |
99.5±0.9 |
Dark |
100.0±0.1 |
|
|
100.7±1.1 |
99.6±1.0 |
|
Unknown A |
Irradiated |
0.0±0.0 |
0.0±0.0 |
2.0±2.9 |
0.0±0.0 |
0.0±0.0 |
Dark |
0.0±0.0 |
|
|
0.0±0.0 |
0.0±0.0 |
|
Total Extractable Residues |
Irradiated |
100.0±0.1 |
99.9±0.0 |
99.7±0.3 |
99.9±0.4 |
99.5±0.9 |
Dark |
100.0±0.1 |
|
|
100.7±1.1 |
99.6±1.0 |
|
CO2 |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Volatile Organic |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Total Volatile Organic |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Bound to Apparatus Walls |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Total % Recovery |
Irradiated |
100.0±0.1 |
99.9±0.0 |
99.7±0.3 |
99.9±0.4 |
99.5±0.9 |
Dark |
100.0±0.1 |
|
|
100.7±1.1 |
99.6±1.0 |
Transformation of test item, expressed as percentage of applied radioactivity (mean ± s.d.), in pH 7 buffer solution.
|
Sampling Times [days] |
|||||
Day 0 |
Day 1 |
Day 3 |
Day 7 |
Day 9 |
||
Test item |
Irradiated |
100.0±0.1 |
100.4±0.3 |
100.7±0.1 |
100.6±0.1 |
100.1±0.2 |
Dark |
100.0±0.1 |
|
|
100.2±0.0 |
102.0±1.2 |
|
Total Extractable Residues |
Irradiated |
100.0±0.1 |
100.4±0.3 |
100.7±0.1 |
100.6±0.1 |
100.1±0.2 |
Dark |
100.0±0.1 |
|
|
100.2±0.0 |
102.0±1.2 |
|
CO2 |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Volatile Organic |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Total Volatile Organic |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Bound to Apparatus Walls |
Irradiated |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
n/a±n/a |
Dark |
n/a±n/a |
|
n/a±n/a |
n/a±n/a |
n/a±n/a |
|
Total % Recovery |
Irradiated |
100.0±0.1 |
100.4±0.3 |
100.7±0.1 |
100.6±0.1 |
100.1±0.2 |
Dark |
100.0±0.1 |
|
|
100.2±0.0 |
102.0±1.2 |
Description of key information
No DT50 values were not derived due to insignificant degradation.
Key value for chemical safety assessment
Additional information
One experimental study is available investigating the phototransformation of the test item in water (M-248236-02-1) which was performed according to EPA Guideline N 161-3. The aqueous phototransformation of radiolabelled test item in two positions was studied at 25 °C (± 0.2 °C) in sterile phosphate buffer solutions (0.01 M potassium phosphate) at pH 7 (range 6.95-7.16) at an initial concentration of 1 mg a.i./L under artificial irradiation (xenon lamp, >290 nm, quartz and Suprax filter). Samples were irradiated continuously for 9 d (equivalent to 30.3 environmental days). A preliminary study demonstrated that no volatiles were formed during photolysis. Therefore, test vessels were not connected to traps for the collection of CO2 and organic volatiles. Duplicate test systems were analyzed at 0, 1, 3, 7, and 9 d, by direct injection HPLC. In the dark test systems, the parent compound did not degrade. There were no major or minor transformation products detected. In the irradiated test systems, the parent compound decreased from 100 % of the applied amount at day 0 to 99.1 % of the applied at the end of irradiation. No major transformation products were detected. The minor transformation products were formed at a maximum of 2.0 % of the applied amount. All of the minor transformation products were transient in nature. The total unidentified radioactivity ranged from 0 to 4.1% of the applied amount. Average material balance for the test item samples was 99.8 ± 0.4% (range = 98.8 % to 100.2 %) of the applied amount. Material balance for the second radio-labelled samples was 100.4 ± 0.3% (range = 99.9% to 100.8%) of the applied amount. The half-life values were not calculated, due to insignificant degradation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.