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EC number: 618-311-0 | CAS number: 898543-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01/2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Test Organisms:
Type: mixed population of aquatic microorganisms (activated sludge)
Origin: aeration tank of a wastewater plant treating predominantly domestic sewage (Wupper area water authority, STP Odenthal)
Date of collection: 2006-11-20
Concentration of inoculum: 30 mg/L ss
Pretreatment of the inoculum:
- the sludge was washed twice by adding mineral medium, centrifuging (10 min at 2000 rpm and 20 °C)
- 0.924 g of the wet sludge was dried in order to calculate the amount of wet sludge to achieve a concentration of activated sludge of 3 g/L (dry wet) suspended solids
- the calculated amount of sludge was first dissolved in mineral medium and then filled up to a defined end volume
- the inoculum was stored at room temperature under continuous shaking with aeration until use for max. 3 days - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Pretreatment of the test item:
- 25 mg of the test item were weighed out on aluminium foil
- test item and aluminium foil were added to the test flask containing 200 mL of mineral medium
- afterwards the flask content was made up to 250 mL with mineral medium containing inoculum to give a test concentration of 100 mg test item/L
Exposure conditions
- Test volume: 250 mL
- Test apparatus: Oxi Top System (WTW)
- Mixing: 1 magnetic stirrer per test vessel
- Incubation time: 28 days
- Incubation temperature: 22 +/- 1°C
- pH value after 28 d: 7.5-8.1 - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- Purity 99% ; Batch No. 1206115 50306102
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0.5
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0.2
- Sampling time:
- 21 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Results with reference substance:
- The reference compound showed 86% after 14 days
- Validity criteria fulfilled:
- yes
- Remarks:
- (-Ready biodegradability of reference compound >= 60 percent within 14 days. -In the toxicity control degradation rates > 25 % within 14 days. -Replicates difference < 20%, -Oxygen uptake of blank inoculum =< 60 mg/L. -No pH influence. )
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Within 28 days, no degradation was determined, 0% degradation within 28d. 3-Morpholinone, 4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-, hydrochloride is considered to be "Not Readily Biodegradable". The reference compound sodium benzoate showed 86% degradation after 14 days.
- Executive summary:
To test for its potential of biodegradation, the substance was incubated for 28 days in a continuously stirred 250 mL closed flask (in duplicate) in the dark with an inoculum originally collected from a local, predominantly municipal wastewater treatment plant. In this assay, biodegradation was estimated by biological oxygen demand (BOD) over time. BOD was measured daily by a manometer. The incubation temperature was 22 +/- 1 °C, pH was 7.5-8.1. The concentration of inoculum was 30 mg /L and the one of the substance was 100 mg/L. Degradation was calculated by substracting the amount BOD in the negative (inoculum only) control from that in the substance or positive control at any given time point and divided by the chemical oxygen demand (COD) or thereotical oxygen demand (ThOD). The 28-day degradation was 0% and for the positive control (with reference substance) the biodegrdation was 86%. In conclusion the substance is not readily biodegradable.
Reference
Theoretical oxygen demand: 1.367 mg O2/mg
Description of key information
Within 28 days, no degradation was determined, 0% degradation within 28d. 3-Morpholinone, 4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-, hydrochloride is considered to be "Not Readily Biodegradable". The reference compound sodium benzoate showed 86% degradation after 14 days.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
All validity criteria of the test method were met. The percent degradation of the reference compound sodium benzoate reached the level 86 % after 14 days.
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