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Diss Factsheets
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EC number: 636-196-5 | CAS number: 6902-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Peer reviewed journal
Work performed for academic research and not done for regulatory purposes.
Not all method details are provided, such as water parameters.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 72 hours
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Performed 2023 to guidelines with valid supporting chemistry
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Specified 99% pure
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of all test item concentrations and the control collected at exposure initiation and at exposure termination were chemically determined.
- Vehicle:
- no
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- Use of approved OECD media.
- Test temperature:
- 22.4 - 23.4 C
- pH:
- Approximately 7.5
- Nominal and measured concentrations:
- Nominal 100.0, 33.3, 11.1, 3.7, and 1.23 mg/L plus the control
Geometric mean 82, 26, 7.9, 1.8 and 0.45, mg/L
In samples collected at exposure initiation, the determined concentrations were in the range of 99.2 – 102.2% of nominal concentration
In the samples collected at exposure termination, the determined concentrations were in the range of 13.1 – 68.5% of nominal concentration. This demonstrates instability and is consistent with the known rapid biodegradability. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol within same period of main study Valid
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- IC50
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- yield
- Duration:
- 72 h
- Dose descriptor:
- IC50
- Effect conc.:
- 26 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- IC50
- Effect conc.:
- ca. 13 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- yield
- Details on results:
- Measured figures to be considered more reliable in view of the low recovery in aged media
- Validity criteria fulfilled:
- yes
- Conclusions:
- Considered moderately harmful
In the samples collected at exposure termination, the determined concentrations were in the range of 13.1 – 68.5% of nominal concentration. This demonstrates instability and is consistent with the known rapid biodegradability.
Data source
Reference
- Reference Type:
- publication
- Title:
- Algal toxicity, accumulation and metabolic pathways of galaxolide
- Author:
- Tengda D. et al
- Year:
- 2 020
- Bibliographic source:
- Journal of Hazardous Materials, Volume 384, 15 February 2020, 121360
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Principles of method if other than guideline:
- Performed as part of academic research and not precisely following regulatory guidance
- GLP compliance:
- not specified
- Remarks:
- Academic research
Test material
- Reference substance name:
- 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran
- EC Number:
- 214-946-9
- EC Name:
- 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran
- Cas Number:
- 1222-05-5
- Molecular formula:
- C18H26O
- IUPAC Name:
- 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran
Constituent 1
- Specific details on test material used for the study:
- Specified 95% pure
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Details not provided
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Tested in concentrations up to limit of water solubility
Test organisms
- Test organisms (species):
- Scenedesmus quadricauda
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- IC50
- Effect conc.:
- ca. 0.336 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Details on results:
- Growth rates not specified
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Considered very toxic to aquatic organisms
It is noted that some of the read-across parameters are not met, with Galaxolide having a lower water solubility and higher Log Kow, but the observed high toxicity to invertebrates is typical of the class of substance and typical of many plant extracts of this type.
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